Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom .谁能帮我找篇文献：Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom Trametes versicolor in androgen-dependent and androgen-i

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Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom .谁能帮我找篇文献：Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom Trametes versicolor in androgen-dependent and androgen-i
Int J Oncol. 2001 Jan;18(1):81-8.
Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom Trametes versicolor in androgen-dependent and androgen-insensitive human prostate cancer cells.
Hsieh TC, Wu JM.
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA.
Abstract
The incidence of prostate cancer varies greatly throughout the world; it is highest in African-Americans and lowest in the Asian populations of China, India, and Japan. Geographical differences in both prevalence of latent prostate cancer and mortality have been postulated to be influenced by diverse tumor-promoting and protective factors, both environmental and dietary. Prostate cancer is a tumor with an extremely long latency; the pattern of prostate tumorigenesis, in terms of the display and sequence of appearance of particular molecular or biochemical features, or morphological changes, characterizing different stages of the carcinogenic process, is expected to be heterogeneous. Some insights into tumor heterogeneity and progression can be obtained from studies using cell lines, particularly those derived from different anatomical sites. The present study aims to investigate whether hormone-responsive LNCaP and androgen-refractory JCA-1, PC-3, and DU-145 prostate cancer cells are responsive to Yunzhi (YZ), a proprietary dietary supplement prepared from extracts of Trametes versicolor, also known as Coriolus versicolor (a mushroom consumed by Chinese for its purported health benefits), and to elucidate its mechanism of action. Ethanolic extracts (70%) of YZ significantly reduced LNCaP cell growth, down-regulated the levels of secreted PSA, but had less effects on the expression of intracellular PSA and did not affect levels of the androgen receptor. In androgen-unresponsive prostate cancer cells, YZ had a much less pronounced suppressive effect on proliferation of PC-3 and DU-145 cells, compared to LNCaP, and was inactive against JCA-1 cells. Western blot analyses show that the expression of Rb, a key regulatory protein in G1/S transition, and PCNA, integrally involved in mammalian cell DNA replication, were significantly reduced by treatment with YZ in PC-3 and DU-145 cells, respectively. In contradiction, none of these biochemical parameters were affected in JCA-1 cells under identical treatment conditions. Further analysis shows that YZ increased the levels of signal transducer and activator family of transcription factors STAT 1 and STAT 3 in JCA-1 and not LNCaP cells. The greater sensitivity of LNCaP cells to this polysaccharopeptide raises the possibility that YZ may be considered as an adjuvant therapy in the treatment of hormone responsive prostate cancer; additionally, it may have chemopreventive potential to restrict prostate tumorigenic progression from the hormone-dependent to the hormone-refractory state.

Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom .谁能帮我找篇文献：Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom Trametes versicolor in androgen-dependent and androgen-i 急求一篇文献：Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom ..谁能帮我找篇文献：Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom Trametes versicolor in androgen-de III-2.A tumor suppressor gene encodes a protein that:A transduces cell growth signalB suppresses translation of proto-oncogenesC suppresses and regulates cell growthD repairs mutations in RNA 英语翻译大写字母不用翻译One central molecule involved in cell growth is p70S6K which is regulated by both the Ras/PI3K/PTEN/Akt/mTOR and Ras/Raf/MEK/ERK pathwaysThe p70S6K gene is amplified in approximately 9% of primary breast cancers an Cell growth and proliferation require ribosomal biogenesis这句话中 ribosomal biogenesis应该怎么翻译? 英语翻译In breast cancer studies,estrogen responsive and nonresponsivebreast cancer cell lines have been extensively used for elucidating the factors responsible for cell growth and for developing new strategies to inhibit cell growth.Ourexperime gene-/- Gene 想要下一篇英文文献急需帮助Enhanced chondrogenesis through specific growth factors in a buffalo embryonic stem cell model.Bone morphogenetic protein 15 and fibroblast growth factor 10 enhance cumulus expansion,glucose uptake,and expressio growth and maintenance是什么意思 transformation and growth是什么意思 growth for the sake of growth is the ideology of the cancer cell 英语翻译gene A encodes a protein with an x domain.Most of X domain-containing proteins are involved in the DNA damage response.Please write a proposal to explore if gene A involved in DNA damage response in cell lines and tumorigenesis in animal 英语翻译Upregulation of growth-restricting imprinted genes,including in the H19–Igf2 locus,in long-term haematopoietic stem cells and their downregulation upon haematopoietic stem cell activation and proliferation. 英语翻译Recurring cycles of cellular growth and division present a simplequestion:how do cells link these processes and divide only uponreaching an appropriate size?Genetic screens have identified com-ponents in the fission yeast controlling cell 英语翻译Objective To observe the in vitro growth inhibitory and apopto sis-inducing effects of paclitaxel on the human osteosarcoma cell line U2- OS.Methods U-2 OS cells were treated with various concentrations of paclitaxel.Proliferation was det 英语翻译NF1 is an autosomal dominant disorder primarily affecting the development and growth of nerve cell tissues.It is known that various kinds of pigmented skin lesions are associated with neurofibromatosis (NF),including café-au-lait spots,a 跪求英译中!不要在线翻译的,谢谢!Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosisRoberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fr